Vitamin B-12 or cyanocobalamin has vital functions in the nervous system and cell division or reproduction. Has been used medically as a “tonic and regenerator.” It is known that B-12 can cure pernicious anemia, but some doctors have reported that their patients are much improved symptoms such as appetite, mood, general vigor, ., and recover more quickly from surgery even without apparent deficiencies of B-12 Although it is not known well conducted studies documenting these clinical observations, recent findings show that the benefits that doctors have reported clinically, may have good scientific support
Vitamin B12 Metabolism :
Under physiological conditions there are 3 types of proteins that bind to vitamin B12 for absorption:
- bullet haptocorrin
- bullet intrinsic factor
- bullet to transcobalamin
- The vitamin is released in food by the action of acid and pepsin in the stomach, here it joins with haptocorrin secreted in saliva with an affinity that the pH of gastric juice acid persists.
Haptocorrin duodenum hydrolyzed by pancreatic enzymes and cobalamin binds to intrinsic factor secreted from the stomach, which presumably involves protecting it from proteolytic enzymes. This complex is taken up by a specific receptor in the ileum.
Receptor binding trains B12-intrinsic factor complex into enteric cells; within the cell degrades the intrinsic factor and cobalamin is released, binding to transcobalamin II which transports it to the portal circulation
This vitamin functions as a cofactor in the metabolism of proteins, fats and carbohydrates. would be assimilated into the small intestine in the presence of intrinsic factor is secreted in the stomach. When it comes to fail, not the B-12 assimilates and can cause the pernicious anemia.
Although this vitamin is water soluble, like other B complex, the body has some capacity for recycling. Deficiency symptoms may be delayed until more than a year after a low intake of the vitamin.
The body uses to manufacture B12 to produce blood cells and other tissues, as well as the coating of the nerves (myelin).
Functions of Vitamin B12
- Prevent and cure pernicious anemia.
- Protects from damage precancerous lung cells of smokers.
- Development and maturation of red blood cells.
- Essential in the utilization of carbohydrates, fats and proteins.
- Collaborate in the manufacture of the myelin sheath on nerves.
- Manufacture of DNA.
- Transport and storage of folate in cells.
- Clinical Picture
The body quickly recovers vitality and energy after correcting a deficiency of B-12. As this vitamin acts in the utilization of carbohydrates and fats (the two main sources of energy) is quite understandable that the energy is improved when vitamin deficiencies resolved.
Many physicians have used vitamin to increase energy in people with chronic fatigue or unexplained extreme tiredness, even without showing more advanced symptoms of vitamin deficiency. The results have been so positive and is still used in this way.
In fact, one of the criteria for therapeutic indication is when states use “physical or mental fatigue are presented. Adynamia “(weakness or lack of energy). Possibly one of the effects of mild deficiencies, sub-clinical and why it works. currently are no studies that are shedding new light on it.
It has long been known that the B-12 is important in the nervous system and its operation. Recent studies have shown that supplementation with B-12, even before clear symptoms of deficiency, improve neuro-psychological symptoms such as memory, disorientation, low reflexes, weakness, fatigue, psychiatric disorders, pain perception and sensitivity of touch.
B12 deficiency causes neurological disorders such as depression, varying mood, confusion, agitation, psychosis and sometimes coma.
It is known that smokers have lower levels of B-12, folic acid and other nutrients. For the relationship of these vitamins with cell division, there have been studies with smokers taking 500 Mg. B-12 and 10 Mg. folic acid daily (having a control group). After a period with vitamins precancerous cell formation was evaluated. was observed that subjects treated with B-12 and folic acid were less of such cells which can lead forming a bronchial or lung tumors.
Other studies have shown that the B-12 can promote protection substances causing allergic reactions. have been tested how sensitive to sulfites (a chemical additive used in dried fruit and wine). greater resistance is observed sulfites in people taking B-12 than in those not taking it. This suggests that B-12 may have other common means protection and environmental toxins. further studies are needed to verify this possibility.
In summary, we can say that B12 deficiency is extensive and every day are adding more symptoms. their theological implications Some of you will mention later.
- Fatigue or tiredness
- Lack of appetite and nausea
- Numbness and tingling in the extremities
- Changes in behavior
- Overactive reflexes
- Fever of unknown origin
- Frequent respiratory infections
- Memory problems
- Dolores tongue
- Megaloblastic anemia and
- disorders of peripheral nerves and spinal cord
- Depression variable mood, confusion, agitation and sometimes eat
- Dementia is common
- invigorates the immune system
- Cardiovascular prevention by lowering homo cysteine levels
Other Sources of B12 :
You can mouth produce B12? This is a very good question. audience Messina in 1996 the fact the bacteria in the oral cavity can produce corroides in small amounts. What is not known is that if similar (vitamin B12 does not work, even prevents the absorption of the active) or actively. Its clinical and preventive value so far not known
bullet Messina M, Messina V. The Dietitian’s Guide to Vegetarian Diets. Gaithersburg, MD: Aspen Publishers, Inc., 1996.
Moh years and Bacteria
Interestingly Robbins in 1950, reported that bacteria and molds can synthesize B12. reported also that the stems and roots of some plants produced up to 0.01 microgram of B12.
bullet WJ Robbins, Hervey A, Stebbins ME. “Studies on vitamin B12 Euglena and” Science 1950 (Oct 20): 455
Herbert reported for vegetarians Iranians certain plants grown with fertilizer from human feces. They consume these plants without much washing. rarely have B12 deficiency. also tells us of the fact that certain beans contain bacteria in their roots B12 produced in India.
Fermented foods containing B12 but most is inactivated, which is not absorbed even interfere. B12 was found in organics but its amount is very little
Nutritional yeast, Saccharomyces cerevisiae, the nutritional yeast is grown on molasses and has a cheese flavor. This is different from the yeast that is used for beer production. B12 concentration is negligible
Mozafar and Oertli in 1992 in Switzerland, B12 added to the land where they cultivated soy plant and found that their levels after culture remained high. He concluded that B12 is stable for court time.
bullet Mozafar A, Oertli JJ. “Uptake of microbially-produced vitamin (B12) by soybean roots” Plant and Soil 1992, 139: 23-30
bullet Mozafar A. “Enrichment of some B-vitamins in plants with application of organic fertilizers” Plant & Soil 1994, 167: 305-311
He remains one of the proposers of the consumption of plants grown with organic products instead of synthetic fertilizers. ‘s believed that this is the reason why some vegetarians do not develop vitamin deficiency.
But if we carefully analyze their study, to meet the daily dose of B12, rates would have to eat 53 raw spinach or 5 cups of cooked barley or twelve rate